منابع مشابه
Systematic Review: Pigmented Odontogenic Lesions
Abstract Introduction: Pigmented odontogenic lesions are rare; to date, only 60 cases have been reported in the literature. Melanocytes have been detected in a wide variety of odontogenic lesions. Several studies have discussed melanocyte presence and melanin production in odontogenic lesions, but its origin is still unclear. Therefore, the present systematic review aimed to gather information...
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Downloa ent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in igenesis and cancer progression have generated significant interest in therapeutic agents that ctly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function 4E in translation initiation and cancer, present evidence supporting its role in cancer initiati...
متن کاملMole Evid
Downlo ptive response (AR) is a term describing resistance to ionizing radiation–induced killing or formation of nt chromosomes that is mediated by pre-exposure to low ionizing radiation doses. The mechanism of ains elusive. Because cell killing and chromosome aberration formation derive from erroneous procesf DNA double-strand breaks (DSB), AR may reflect a modulation of DSB processing by nonh...
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Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...
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Downlo inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent ting mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were sento a novel series of Raf inhibitors (e.g., B-Raf A375, IC50 on cells = 2 nmol/L; ED50 on tumor rafts = 1.3 mg/kg). However, in cells and tumors with wild-type B-Raf, exposure to Raf inhib...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1934
ISSN: 0035-9157
DOI: 10.1177/003591573402800216