PICking H3K4me3

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The Association Between H3K4me3 and Antisense Transcription

Histone H3 lysine 4 trimethylation (H3K4me3) is well known to occur in the promoter region of genes for transcription activation. However, when investigating the H3K4me3 profiles in the mouse cerebrum and testis, we discovered that H3K4me3 also has a significant enrichment at the 3' end of actively transcribed (sense) genes, named as 3'-H3K4me3. 3'-H3K4me3 is associated with ~15% of protein-cod...

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ژورنال

عنوان ژورنال: Nature Structural & Molecular Biology

سال: 2013

ISSN: 1545-9993,1545-9985

DOI: 10.1038/nsmb.2561