PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively
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چکیده
منابع مشابه
PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
The tree-like architecture of the mammary gland is generated by branching morphogenesis, which is regulated by many signals from the microenvironment. Here we examined how signaling downstream of phosphoinositide 3-kinase (PI3K) regulates different steps of mammary branching using three-dimensional culture models of the mammary epithelial duct. We found that PI3K was required for both branch in...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2013
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2013.04.029