Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways
نویسندگان
چکیده
منابع مشابه
HZ08 Reverse P-Glycoprotein Mediated Multidrug Resistance In Vitro and In Vivo
BACKGROUND Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. METHODS MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibition and P-gp ATPase assays were used to confirm the P-gp inhibition capability of HZ08. Furtherm...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2021
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2021.111632