Phytochemical Screening, GC-MS and FTIR analysis of Bioactive Compounds in Methanolic Leaf Extracts of Costus igneus (CIMLE) as a Natural Source of Drug Lead Molecules for Next-generation Drug-design, Development and Therapeutics

Diabetes mellitus (DM) is a metabolic disorder that affects people of all ages. Increased prevalence diabetes worldwide has led to the development synthetic drugs provide an interim solution ill effects issue. However, such drugs, although effective as antihyperglycemic agents, are accompanied by significant side effects, costly, and inaccessible majority in remote underdeveloped countries. Local medicinal plants have been used indigenous through ages treat complicate ailments due their ease availability GRAS nature. As continues become prevalent, health care practitioners considering PBNPs potential source antidiabetic high potency fewer effects. To better understand mechanism action plants, active phytoconstituents being isolated investigated thoroughly. Phytochemical screening followed GCMS analysis methanolic leaf extracts Costus igneus depicted presence 19 bioactive compounds viz., Bicyclo [3.1.1]heptane, 2,6,6- trimethyl-; 2-Pentadecanone, 6,10,14-trimethyl-; phthalic acid; 3,7,11,15-Tetramethyl-2-hexadecen- 1-ol; 5,9,13-Pentadecatrien-2-one, 6,10,14- trimethyl; 2(3H)-Furanone,dihydro-5-methyl-5- pentyl; Hexamethyl-2,6,10,14,18,22- tetracosahexaen-1-yl]-6-methox.; Oxalic acid, cyclohexyl isohexyl ester; 6-Octadecenoic Phytol; 4,8,12,16-Tetramethylheptadecan-4- olide; 5-methyl-2,3-dihydro-1H-indole; Bis(2-ethylhexyl) phthalate; Adamantane-1-carboxylic acid methyl Benzopyran-6-ol,3,4-dihydro-; Benzoquinoline; gamma-Tocopherol; dimethyl-5,5'-diphenyl-1H,; 1H-benzo[b]furo[2,3-f]indole may be ADMET predicted for biomedical application treatment diabetics long term complications associated with disease. 
 Keywords: igneus; CIMLE; GCMS; Screening; Antidiabetic Leads; NDDT; Medicinal Plant