Phytochemical and metabolic profiling of the different Podocarpus species in Egypt: Potential antimicrobial and antiproliferative activities

Podocarpus is the most dominant genus of Podocarpaceae, with higher taxonomical proximity to Taxaceae, having numerous pharmaceutical applications, however, scarce studies dealing physiological and metabolic criteria in Egypt were reported. Thus, objective this work was assess metabolical patterns different species Podocarpus; P. gracilior, elongates, macrophyllus neriifolius. The highest terpenoids contents reported neriifolius, followed by elongatus, macrophyllus. gracilior had antioxidants amount, macrophyllus, neriifolius elongatus. From GC/MS profiling, caryophyllene, β-cadinene, β-cuvebene, vitispirane, β-cadinene amorphene metabolites gracilior. β-Caryophyllene common an obvious fluctuation. plant methanolic extracts have activity against multidrug resistant bacteria; E. coli, aeruginosa, S. pyogenes aureus, fungi; A. fumigatus, flavus, niger C. albicans a concentration-dependent manner. Taxol yield assessed elongatus (16.4 μg/gdw), chemical identity derived from resolved LC/MS, molecular mass 854.6 m/z, similar structural fragmentation pattern authentic one. antitumor extracted towards HCT-116 (30.2 μg/ml), HepG-2 (53.7 μg/ml) MCF-7 (71.8 μg/ml). ITS sequence “as potent producer” deposited on Genbank accession #ON540734.1, that first record Genbank.