Physiology of protease-activated receptors (PARs): involvement of PARs in digestive functions
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چکیده
منابع مشابه
Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles.
Proteinase-activated receptors (PARs), a family of G protein-coupled receptors, are widely distributed in the mammalian body, playing a variety of physiological/pathophysiological roles. In the respiratory systems, PARs, particularly PAR-2 and PAR-1, are expressed in the epithelial and smooth muscle cells. In addition to the G(q/11)-mediated activation of the phospholipase C beta pathway, epith...
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Correspondence to: Dr N Vergnolle, Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW Calgary, Alberta, Canada T2N4N1; [email protected] _________________________ O f all the body systems, the gastrointestinal tract is the most exposed to proteinases. Under physiological conditions, digestive pr...
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Correspondence to: Dr N Vergnolle, Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW Calgary, Alberta, Canada T2N4N1; [email protected] _________________________ O f all the body systems, the gastrointestinal tract is the most exposed to proteinases. Under physiological conditions, digestive pr...
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The substantia nigra pars reticulata (SNr) is a key basal ganglia output nucleus. Inhibitory outputs from SNr are encoded in spike frequency and pattern of the inhibitory SNr projection neurons. SNr output intensity and pattern are often abnormal in movement disorders of basal ganglia origin. In Parkinson's disease, histamine innervation and histamine H3 receptor expression in SNr may be increa...
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Proteases acting at the surface of cells generate and destroy receptor agonists and activate and inactivate receptors, thereby making a vitally important contribution to signal transduction. Certain serine proteases that derive from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast cell and neutrophil proteases), and from multiple other sources (e.g., epithelial cells,...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1999
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.114.supplement_173