Physiology of magnesium metabolism and the use of magnesium in intensive care (part 2)

In the second part of review, aspects changes in magnesium metabolism under conditions severe stress, mechanisms anti-stress protection body with participation magnesium, features water-electrolyte at cellular level, anti-inflammatory effect and role processes detoxification acute poisoning certain poisons are consi-dered. The main body’s defence to suppress oxidative stress by limiting production hormones, intake ionized calcium sodium into cells a decrease severity transmineralization retention body, suppressing action factors that initiate development inflammation reducing pro-inflammatory mediators, blocking protecting glutamate receptors. Magnesium therapy can help keep effective energy critical maintaining functioning Na+/K+-ATPase, work Na+/H+-exchanger, helping reduce acidosis. prescription sodium-magnesium antiporter discussed. Hypertonic solutions sulfate being injected high rate create rapid low-volume fluid resuscitation, thereby eliminating dangerous effects hyperchloremia hypernatremia occur when using hypertonic chloride solutions. toxico-logy, preparations used protect exposed heavy metals, organophosphorus compounds. They also caused inhibit excess endogenous carbon monoxide, limit free radical damage its pathological effect. During detoxification, prevents depletion antioxidant system maintain sufficient levels glutathione other antioxidants cells.