Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide: Should Consideration Be Given to Cannalicular Efflux Transporters?
نویسندگان
چکیده
منابع مشابه
Response to Physiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide—Should Consideration Be Given to Cannalicular Efflux Transporters?
To the Editor: We thank Dr Srinivas for the thought-provoking comments and the opportunity to clarify a number of aspects of our work. With reference to Figure 2 from RUN8, the residual error model has been weighted by the inverse square root of the number of patients within each study so as to prioritize the impact of studies with higher subject numbers. For example, although the studies that ...
متن کاملPhysiologically Based Pharmacokinetic Model for Prediction of Leflunomide and Teriflunomide: Should Consideration Be Given to Cannalicular Efflux Transporters?
Given the growing importance of leflunomide in rheumatoid arthritis therapy, it is essential to understand its disposition by considering physiological processes such as CYP enzymes (intestine and liver), transporters (mostly efflux), and systemic conversion (blood). This has led to the development of an impressive semiphysiologically based pharmacokinetic (semi-PBPK) model by Hopkins et al. (“...
متن کاملI-14: Assisted Reproduction and Religion What Consideration Should Be and Should Not Be Relevant,
Several important issues are pertinent to an ethical discussion of the new technology today grouped under the name Assisted Reproduction Technology (ART). This is a moral imperative because each of us must decide what is to be considered ethically acceptable in assisted reproduction. Reflecting on the ethical dimension of ‘creating’ a new human life can play a major role in ensuring that in eac...
متن کاملPhysiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
متن کاملA Physiologically-Based Pharmacokinetic Model for Vancomycin
A Physiologically-Based Pharmacokinetic Model for Vancomycin
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2015
ISSN: 2163-8306,2163-8306
DOI: 10.1002/psp4.12033