Physiological mechanisms of thalamic ventral intermediate nucleus stimulation for tremor suppression

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Thalamic Ventral Intermediate Nucleus Deep Brain Stimulation for Orthostatic Tremor

BACKGROUND Orthostatic tremor (OT) was first described in 1977. It is characterized by rapid tremor of 13-18 Hz and can be recorded in the lower limbs and trunk muscles. OT remains difficult to treat, although some success has been reported with deep brain stimulation (DBS). CASE REPORT We report a 68-year-old male with OT who did not improve significantly after bilateral thalamic stimulation...

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INTRODUCTION Medically refractory tremor treatment has evolved over the past half-century from intraoperative thalamotomy to deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM). Within the past 15years, unilateral radiosurgical VIM thalamotomy has emerged as a comparably efficacious treatment modality. METHODS An extensive literature search of VIM DBS series was pe...

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BACKGROUND Orthostatic tremor is an uncommon disorder manifest by high frequency, low amplitude leg tremor upon weight bearing. Treatment with oral tremor agents is inconsistent and usually not satisfactory. METHODS We implanted bilateral ventralis intermedius nuclei deep brain stimulators into an 82-year-old male with refractory orthostatic tremor. RESULTS The patient had a marked subjecti...

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ژورنال

عنوان ژورنال: Brain

سال: 2018

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awy139