Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development.

Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of physiological and pathophysiological roles during central nervous system (CNS) development. In addition to participating in neuronal signal transduction, EAAs also exert trophic influences affecting neuronal survival, growth and differentiation during restricted developmental periods. EAAs also participate in the d...

Role of excitatory amino acids on somatostatin production in the central nervous system.

since dibutyryl cyclic A M P also stimulates cell growth. T h e mcchanism is unknown; however. other workers. e.g. Rozengurt e/ ( I / . (261 reported that a sustained increase in cellular cyclic A M P acts as ii mitogenic signal for Swiss 3T3 cells. There is also a report 1271 that the catalytic subunit of cyclic A MP-dependent protein kinase may be involved in regulation o f the proto-oncogene...

Physiological and pathophysiological functions of the endocannabinoid system in the central nervous system

Physiological and Pathophysiological Functions of the Endocannabinoid System in the Central Nervous System

Introduction All the constituents of the endocannabinoid system (ECS) are widely expressed throughout the adult nervous system, but they are also highly present during gestation in the developing central nervous system. A particularly interesting observation is that the cannabinoid receptor type 1 (CB1 receptor) is expressed in two very different neuronal subpopulations: in inhibitory GABAergic...

Excitatory amino acids: physiological and pharmacological probes for neuroscience research.

The 2S,3S,4S-isomer (L-CCG-I) of 2-(carboxycyclopropyl)glycine (CCG) is a potent metabotropic glutamate receptor agonist. L-CCG-I depressed monosynaptic excitation in the newborn rat spinal motoneurone at low concentrations well below those causing postsynaptic depolarization. 2S,3R,4S-CCG (L-CCG-IV) is a potent N-methyl-D-aspartate (NMDA)-type agonist. In cultured rat hippocampal neurones, L-C...