Physiological and histological Study on liver of male albino rats treated with retinol drug (retain)

Isotretinoin, commonly known as 13-cis-retinoic acid, is a vitamin derivative used to treat severe acne and several types of skin, head, neck cancer. According certain research, isotretinoin causes apoptosis in number different bodily cells. In instances clinically obvious acute liver injury with jaundice, has not been definitively linked. It unknown how elevates serum aminotransferase levels, however, given that this effect seems occur more frequently greater dose medication, it may be direct harmful impact. Methods: This study was conducted the animal house College Science / University Babylon for period from 22/11/2021 22/12/2021. The included 40 white male albino rats (Rattus rattus) aged 2-3 months, weighing 100 150 g, at temperature (25+3C) 12 u (light-dark cycle) then divided into eight groups, each group containing five rats. animals were left before treatment two weeks acclimatize. After that, treated Isotretinoin they free water ration.