PHYSIOLOGICAL ALTERATIONS OF MITOCHONDRIA UNDER DIABETES CONDITION AND ITS CORRECTION BY POLYPHENOL GOSSITAN

نویسندگان

چکیده

The state of lipid peroxidation (LPO), respiration and oxidative phosphorylation, mitochondrial permeability transition pore (mPTP) antiradical activity rat liver mitochondria in streptozotocin (STZ)-induced diabetes condition were studied, considered the ways correction detected membrane damages with use gossitan, isolated from cotton plant Gossypium hirsutum L. It was shown that rate states V3 V4 increases during STZ-induced diabetes, which significantly reduces respiratory control (RC) ADP/O coefficients comparison control. findings suggest uncoupling phosphorylation takes place diabetes. conditions swelling is higher than healthy ones; this means mPTP open state. Gossitan recovers to normal condition, thereby removing effect STZ on mitochondria. (per os dose 10 mg/kg body weight, 8 days) eliminates functional disorders mitochondria, probably due its antioxidant properties.

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ژورنال

عنوان ژورنال: The Journal of Microbiology, Biotechnology and Food Sciences

سال: 2022

ISSN: ['1338-5178']

DOI: https://doi.org/10.55251/jmbfs.2224