Physicochemical, Toxicity and Antioxidant Activity of Terminalia catappa Kernel Oil in Mice

Pharmacognosy Research,2023,15,1,119-127.DOI:10.5530/097484900304Published:December 2022Type:Original ArticleAuthors:Emmanuel Mshelia Halilu, Chinenye Jane Ugwah-Oguejiofor, Göksu Oduncuo?lu, and Solomon Gamde Matthias Author(s) affiliations:Emmanuel Halilu1,4,*, Ugwah-Oguejiofor2, Oduncuo?lu1, Matthias3 1Department of Pharmacognosy, Faculty Pharmacy, Cyprus International University, Nicosia, North Cyprus, Mersin 10, TURKEY. 2Department Pharmacology Toxicology, Pharmaceutical Sciences, Usmanu Danfodiyo Sokoto, NIGERIA. 3Department Histopathology, Health Sciences Technology, University Jos, Plateau, 4Department Ethnopharmacy, Abstract:Background: Terminalia catappa Linn. is an ornamental tree belonging to the family Combretaceae. This study was aimed at evaluating toxicity profile antioxidant activity oil. Materials Methods: Oral acute sub-acute were studied in mice using Organization for Economic Co-operation Development (OECD) guidelines. The assessed DPPH free radical. Results: seed oil demonstrated by scavenging radical with IC50 1.425 mg/mL while tannic acid (standard) 5.005 mg/mL. oral LD50 greater than 5000 mg/kg. study, produced no significant difference weight biochemical parameters treated animals compared control. Conclusion: also non-toxic liver, kidney, heart lungs on histopathological examination. Our results indicated that not toxic contains beneficial phytochemical activity. Keywords:Antioxidant, DPPH, Phytochemical, catappa, Toxicity.View:PDF (520.27 KB)