Physicochemical stability of cimetidine amorphous forms estimated by isothermal microcalorimetry
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چکیده
منابع مشابه
Standards in Isothermal Microcalorimetry
The main calorimetric principles used in isothermal microcalorimetry are briefly discussed. Different chemical calibration and test reactions are discussed, with a focus on reactions suitable for ambient conditions: reactions initiated by mixing of liquids (including titration microcalorimetry), dissolution of solid compounds and of slightly soluble gases, a photochemical process, and thermal p...
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Techniques of isothermal microcalorimetry have been much improved during the past two decades. In addition to their use in fundamental research, applications of practical importance have been established in some areas. However, no significant use of isothermal microcalorimetry has yet been seen in practical applications of biology, despite many methodological studies reported from that area. Th...
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inTroDuCTion When a problem is encountered in the production or storage of solid dosage forms, invariably the problem is somehow connected to the sorption of water. In the presence of water, the physical properties of solids may be altered causing changes in flow properties, free volume, and compressibility; or there may be an accelerated interconversion between polymorphic forms seriously affe...
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When a promising new compound enters early development, studies are conducted to determine the properties of the drug under various chemical and physical conditions in order to find a formulation suitable for use in clinical trials. Measuring both the chemical and physical stability of the drug candidate is an important part of early phase development since the shelf life of the compound will u...
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Isothermal heat conduction microcalorimetry was used to evaluate chemical stability of a solid drug in tablets. A variety of mixtures were compressed to flat faced tablets of 300 mg weight and 10 mm diameter. The content of drug amounted to 10%. Besides drug containing tablets, also placebo tablets as well as the non compressed mixtures were examined by microcalorimetry at 80 degrees C. The exc...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2002
ISSN: 1530-9932
DOI: 10.1208/pt030430