Physicochemical Properties of Silibinin-Phosphatidylcholine Complex and its Implications for Drug Formulations

Silibinin, an active constituent of silymarin possesses several medicinal properties. Although, the poor water solubility and less bioavailability restrict clinical utility silibinin, complex silibinin phosphatidylcholine manifested outstanding biological activities in vivo. Thereby, was prepared with (1:2, w/w) for better therapeutic efficacy their physicochemical properties were analyzed. Thermal analysis, nuclear magnetic resonance Fourier transform infrared spectroscopy data revealed that improved binding efficiency non-covalent interactions. Kinetics vitro drug release high performance liquid chromatography analysis showed silibinin-phosphatidylcholine released maximum 30 %-32 % into phosphate-buffered saline between 3 h to 6 at pH 7 37°. Release profile from Swiss albino mice suggested increased concentration three times more plasma samples than individual treatment after 10 d. Furthermore, no significant changes observed body weight diet consumption throughout study. Therefore, study improves which explains potential its form against various disorders including cancer.