Physical-organic molecular biology: pathway and stability of protein folding
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چکیده
منابع مشابه
Physical-organic molecular biology: pathway and stability of protein folding
Protein engineering, the design and synthesis of novel proteins by genetic engineering, allows complex problems in molecular biology to be studied by structure-activity relationships in an analogous manner to the application of physical-organic chemistry to simple organic molecules. This approach has been applied to study the folding pathway and stability of barnase, the RNAse from Bacillus amy...
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It is well-known that the typical protein’s three-dimensional structure is relatively unstable in harsh conditions. A practical approach to maintain the folded state and thus improve the stability and activity of proteins in unusual circumstances is to directly apply stabilizing substances such as osmolytes to the protein-containing solutions. Osmolytes as natural occurring organic molecules ty...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1991
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac199163020187