Physical and Functional Interaction of Growth Hormone and Insulin-Like Growth Factor-I Signaling Elements
نویسندگان
چکیده
منابع مشابه
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
Reduced IGF-I/insulin signaling and caloric restriction (CR) are known to extend the life span and delay age-related diseases. To address the interaction of these two interventions, we subjected normal (N) and long-lived GH receptor knockout (GHRKO) mice to CR for 20 months starting at weaning. We also used bovine GH transgenic (bGH Tg) mice, which overexpress GH and are short-lived and insulin...
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Purpose: The limited availability of donor sites for nerve grafts continues to stimulate research toward finding suitable alternatives. Material and Methods: In the following study, the effects of direct administration of Nerve Growth Factor (NGF), Insulin - Like Growth Factor - I (IGF-I) , or / and collagen gel into Polyvinylidene Fluride (PVDF) gap was tested in a rat sciatic nerve model. A ...
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The aim of the GH-2000 project is to develop a method for detecting GH doping among athletes. Previous papers in the GH-2000 project have proposed that a forthcoming method to detect GH doping will need specific components from the GH/IGF-I axis and bone markers because these specific variables seem more sensitive to exogenous GH than to exercise. The present study examined the responses of the...
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Purpose: The present study was conducted to investigate the effect of 8 weeks resistance training with and without vascular occlusion on physical fitness indexes, growth hormone, and Insulin-like growth factor 1 (IGF-1) in male judokas. Methods: In this quasi-experimental study, 20 male judokas were divided into two groups: 1. Traditional resistance training along with judo training with...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2004
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2003-0418