Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
نویسندگان
چکیده
منابع مشابه
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.
Melanoma is difficult to treat once it becomes metastatic. However, the precise ancestral relationship between primary tumors and their metastases is not well understood. We performed whole-exome sequencing of primary melanomas and multiple matched metastases from eight patients to elucidate their phylogenetic relationships. In six of eight patients, we found that genetically distinct cell popu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1508074112