Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis
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منابع مشابه
Phrenic long-term facilitation after acute intermittent hypoxia requires spinal ERK activation but not TrkB synthesis.
Acute intermittent hypoxia (AIH) elicits a form of spinal respiratory plasticity known as phrenic long-term facilitation (pLTF). pLTF requires spinal serotonin receptor-2 activation, the synthesis of new brain-derived neurotrophic factor (BDNF), and the activation of its high-affinity receptor tyrosine kinase, TrkB. Spinal adenosine 2A receptor activation elicits a distinct pathway to phrenic m...
متن کاملPhrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.
Episodic hypoxia evokes a sustained augmentation of respiratory motor output known as long-term facilitation (LTF). Phrenic LTF is prevented by pretreatment with the 5-hydroxytryptamine (5-HT) receptor antagonist ketanserin. We tested the hypothesis that 5-HT receptor activation is necessary for the induction but not maintenance of phrenic LTF. Peak integrated phrenic nerve activity (integralPh...
متن کاملPhrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.
Respiratory long-term facilitation (LTF) is a form of serotonin-dependent plasticity induced by intermittent hypoxia. LTF is manifested as a long-lasting increase in respiratory amplitude (and frequency) after the hypoxic episodes have ended. We tested the hypotheses that LTF of phrenic amplitude requires spinal serotonin receptor activation and spinal protein synthesis. A broad-spectrum seroto...
متن کاملMammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.
Phrenic long-term facilitation (pLTF) is a persistent increase in phrenic nerve activity after acute intermittent hypoxia (AIH). Distinct cell-signaling cascades give rise to pLTF depending on the severity of hypoxemia within hypoxic episodes. Moderate AIH (mAIH; three 5-min episodes, PaO2 ∼35-55 mmHG) elicits pLTF by a serotonin (5-HT)-dependent mechanism that requires new synthesis of brain-d...
متن کاملSevere acute intermittent hypoxia elicits phrenic long-term facilitation by a novel adenosine-dependent mechanism.
Acute intermittent hypoxia [AIH; 3, 5-min episodes; 35-45 mmHg arterial PO(2) (Pa(O(2)))] elicits serotonin-dependent phrenic long-term facilitation (pLTF), a form of phrenic motor facilitation (pMF) initiated by G(q) protein-coupled metabotropic 5-HT(2) receptors. An alternate pathway to pMF is induced by G(s) protein-coupled metabotropic receptors, including adenosine A(2A) receptors. AIH-ind...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2012
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00098.2012