Photostabilities of Amlodipine OD Tablets in Different Dosage Forms
نویسندگان
چکیده
Amlodipine is a dihydropyridine drug that used to lower high blood pressure. In this study, the photostabilities of orally disintegrating (OD) amlodipine tablets, both original and generic versions, their powdered suspended forms were evaluated. The concentration active pharmaceutical ingredient (API) was monitored by high-performance liquid chromatography (HPLC), revealing residual amounts API in powders suspensions significantly decreased after ultraviolet light (UV) irradiation for 24 hr. OD tablets packaged stored at house pharmacy up 90 days evaluation clinical use, form when they house. ESI-LC/MS/MS analysis performed determine chemical structure photoproducts generated photo-irradiated tablets. It revealed mainly dehydrogenated concomitant with photodegradation UV sunlight irradiation. This first study evaluated medicines, versions altered forms.
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ژورنال
عنوان ژورنال: Chromatography
سال: 2022
ISSN: ['1342-8284', '1348-3315']
DOI: https://doi.org/10.15583/jpchrom.2022.009