Photolytic Labeling To Probe Molecular Interactions in Lyophilized Powders
نویسندگان
چکیده
منابع مشابه
Mass Spectrometric Approaches to Study Protein Structure and Interactions in Lyophilized Powders
Amide hydrogen/deuterium exchange (ssHDX-MS) and side-chain photolytic labeling (ssPL-MS) followed by mass spectrometric analysis can be valuable for characterizing lyophilized formulations of protein therapeutics. Labeling followed by suitable proteolytic digestion allows the protein structure and interactions to be mapped with peptide-level resolution. Since the protein structural elements ar...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2013
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp4004332