Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
Cancer-associated fibroblasts are associated with poor prognosis in esophageal squamous cell carcinoma after surgery.
OBJECTIVE Cancer-associated fibroblasts (CAFs; α-SMA positivity), as a representative of the tumor microenvironment, play an important role in influencing the proliferation, invasion and metastasis of cancer cells. The objective is to investigate the prognostic value of CAFs density in esophageal squamous cell carcinoma (ESCC) after surgery. METHOD A total of 95 patients who underwent esophag...
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The tumor microenvironment has emerged as a novel chemotherapeutic strategy in the treatment of cancer. This is most clearly exemplified by the antiangiogenesis class of compounds. Therapeutic strategies that target fibroblasts within the tumor stroma offer another treatment option. However, despite promising data obtained in preclinical models, such strategies have not been widely used in the ...
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BACKGROUND Cancer-associated fibroblasts (CAF) are activated fibroblasts in the cancer stroma and play an important role in cancer progression. Some reports have indicated the correlation between the expression of CAF markers and adverse prognosis in several cancers. However, no reports have studied CAF phenotype and its clinical relevance in esophageal squamous cell carcinoma (ESCC). METHODS...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2019
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2019.1617566