Photodynamic Therapy of Intratumoral HPD Injection

Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapy.

PURPOSE Photodynamic therapy (PDT), which is used clinically for the palliative treatment of cancer, induces local tumor cell death but has no effect on tumors in untreated sites. The purpose of this study was to determine if local PDT followed by intratumoral injection of naïve dendritic cells (IT-DC) induces systemic antitumor immunity that can inhibit the growth of untreated as well as PDT +...

Study of ALA and small dosage of HPD photodynamic therapy (HPD-PDT) in treatment of skin cancer

Objective: To investigate clinical effect of ALA and small dosage of HPD-PDT in treatment of patients with skin cancer. Methods: From June 2014 to April 2017, 62 cases of malignant skin tumor patients treated in our hospital were selected as the objects and randomly divided into study group (31 cases) and control group (31 cases), respectively treated by ALA and small dosage of HPD-PDT and conv...

Photo-oxidative action in cervix carcinoma cells induced by HPD - mediated photodynamic therapy.

UNLABELLED Photodynamic therapy leads to oxidative stress through the generation of free radicals. Oxidative stress causes damage to cellular macromolecules such as nucleic acids, proteins and lipids. AIM To examine the hematoporphyrin derivative (HpD) - mediated photodynamic effect on cervical adenocarcinoma cell line HeLa. METHODS The HpD localization in HeLa cells was analyzed by confoca...

Intratumoral Injection of CpG

Photodynamic therapy (PDT)

Photodynamic therapy (PDT) is a comparatively novel therapeutic method involving a safe light source and a light-sensitive substance, termed as photosensitizers (PSs), such as methylene blue (MB), toluidine blue (TBO), sulfonated aluminum phthalocyanine, chlorine derivatives, nontoxic indocyanine green (ICG), and curcumin (CUR). (1) The combination of a nontoxic PS with low-intensity visible li...