Phosphoribosyladenosine Monophosphate, an Intermediate in Histidine Biosynthesis
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چکیده
منابع مشابه
Phosphoribosyladenosine Monophosphate, an Intermediate in Histidine Biosynthesis.
The first reaction of histidine biosynthesis, the conversion of 5-phosphoribosyl-1-pyrophosphate and adenosine triphosphate to N-1-(5’-phosphoribosyl)-ATP has been described previously (1, 2). The present report describes the preparation, isolation, and characterization of N-1-(5’-phosphoribosyl)-AMP, the second intermediate in the pathway (Fig. 1). This compound is formed from phosphoribosyl-A...
متن کاملPurification and composition studies of phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase, the first enzyme of histidine biosynthesis.
Highly purified preparations of iV-l-(S’-phosphoribosyl)adenosine triphosphate:pyrophosphate phosphoribosyltransferase from Salmonella fyphimurium have been obtained. The phosphoribosyltransferase is the first enzyme unique to histidine biosynthesis and is sensitive to feedback inhibition by histidine. The procedure used for purification preserved the histidine sensitivity of the enzyme. A mole...
متن کاملHistidine biosynthesis.
Histidine (His) is one of the standard amino acids in proteins, and plays a critical role in plant growth and development. The chemical properties of the imidazole side group allow His to participate in acid-base catalysis, and in the co-ordination of metal ions. Despite the biological importance of this molecule, His biosynthesis has been somewhat neglected in plants, in stark contrast to micr...
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The microsomal fraction of liver has been found to catalyze glucose transfer from UDPG to a lipid acceptor which appears to be identical to the compound obtained by chemical phosphorylation of dolichol. The substance formed (dolichol monophosphate glucose) is acid labile and yields 1,6-anhydroglucosan by alkaline treatment. It can be used as substrate by the enzyme system yielding a glucoprotei...
متن کاملThe Biosynthesis of Histidine
It was later shown (2) that the mutant C84 accumulates imidazoleglycerol’ in the growth medium, that mutant Cl41 accumulates imidazoleglycerol and imidazoleacetol,2 and that T1710 accumulates L-histidinol.3 It was also observed that none of these compounds will replace histidine in promoting the growth of these mutants or other mutants blocked earlier in the sequence. This suggested that these ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97286-8