PHOSPHOPROTEIN PHOSPHATASE IN MAMMALIAN TISSUES
نویسندگان
چکیده
منابع مشابه
Expression of alkaline phosphatase loci in mammalian tissues.
Alkaline phosphatases [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] have been examined in liver, bone, kidney, intestine, and placenta from nine mammalian species by quantitative inhibition and thermostability studies and compared with alkaline phosphatases in the corresponding human tissues. In humans, three kinds of alkaline phosphatase can be sharply differentia...
متن کاملThe properties of particulate phosphoprotein phosphatase.
The very high metabolic activity of protein-bound phosphorus was first discovered by Davidson et al. (1) in P32 uptake experiments and subsequently confirmed in other laboratories. A possible explanation of these findings is that the primary step in oxidative phosphorylation results in the formation of a phosphorylated protein with subsequent transfer of the high energy phosphate to adenosine t...
متن کاملThe intracellular location of phosphoprotein phosphatase activity.
The rapid appearance of radioactivity in the phosphoprotein fraction of tissues after exposure to inorganic radiophosphate was first noted by Davidson et al. (1). This finding was subsequently confirmed in several laboratories for a variety of cell types (2-5). The physiological function of phosphoproteins is obscure, however, since no direct evidence is yet available for their role in cell met...
متن کاملA phosphoprotein phosphatase from ox brain.
1. The pyrophosphate-exchange reactions which are catalysed by rat-liver preparations and depend upon leucine or isoleucine are profoundly modified by 'soluble' ribonucleic acid and by changes in magnesium concentration. The preponderant influence is exerted by the terminal nucleotide sequence of the 'soluble' ribonucleic acid. Lysinedependent pyrophosphate exchange occurs only at relatively hi...
متن کاملCoordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
Dynamic changes in protein phosphorylation govern the transitions between different phases of the cell division cycle. A "tug of war" between highly conserved protein kinases and the family of phosphoprotein phosphatases (PPP) establishes the phosphorylation state of proteins, which controls their function. More than three-quarters of all proteins are phosphorylated at one or more sites in huma...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)57091-5