Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptosis
نویسندگان
چکیده
منابع مشابه
PS218. Phospholipase C-related catalytically inactive protein is involved in the neuroinflammation-induced anorexia
Introduction: Neuroinflammation is involved in the pathophysiology of major depressive disorder. Sickness behavior such as sleep disorder, anhedonia, anorexia, and social withdrawal is observed as lipopolysaccharide (LPS)-induced depressive-like behaviors in mice. LPS stimulates PI3K-Akt signaling via TLR and regulates a variety of cellular processes, including cytokine and chemokine expression...
متن کامل- 1 - Phospholipase C - related , but catalytically inactive protein PRIP modulates SNAP - 25 phosphorylation and exocytosis
Background: Phospho-modulation of SNARE function has not yet known. Results: Phospho-SNAP-25 was de-phosphorylated by protein phosphatase-1 whose activity was regulated by PRIP, thus regulating exocytosis. Conclusion: Protein phosphatase-1 whose activity is regulated by PRIP, is the major phosphatase responsible for the de-phosphorylation of SNAP-25. Significance: The results provide the first ...
متن کاملPhospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortalit...
متن کاملPhospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion
We previously reported that phospholipase C-related catalytically inactive protein (PRIP)-knockout mice exhibited hyperinsulinemia. Here, we investigated the role of PRIP in insulin granule exocytosis using Prip-knockdown mouse insulinoma (MIN6) cells. Insulin release from Prip-knockdown MIN6 cells was higher than that from control cells, and Prip knockdown facilitated movement of GFP-phogrin-l...
متن کاملPhenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice
Phospholipase C-related inactive protein (PRIP) plays important roles in trafficking to the plasma membrane of GABA(A) receptor, which is involved in the dominant inhibitory neurotransmission in the spinal cord and plays an important role in nociceptive transmission. However, the role of PRIP in pain sensation remains unknown. In this study, we investigated the phenotypes of pain behaviors in P...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_po3-7-22