منابع مشابه
Phospholipase A2 Activates Hemostasis
BACKGROUND Phospholipases A(2) (PLA(2)) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein-mediated contact phase of coagulation. The aim of the present study was to expose citrated whole blood to PLA(2) and to quantify thrombin generation in recalcified plasma. METHODS Normal citrated blood was exposed to bovine pancre...
متن کاملGroup VIB Calcium-Independent Phospholipase A2 (iPLA2γ) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice
In platelets, group IVA cytosolic phospholipase A2 (cPLA2α) has been implicated as a key regulator in the hydrolysis of platelet membrane phospholipids, leading to pro-thrombotic thromboxane A2 and anti-thrombotic 12-(S)-hydroxyeicosatetranoic acid production. However, studies using cPLA2α-deficient mice have indicated that other PLA2(s) may also be involved in the hydrolysis of platelet glycer...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Secreted phospholipase A2 induces vascular endothelial cell migration
Secreted phospholipase A2 (sPLA2) regulates a variety of cellular functions. The present investigation was undertaken to elucidate the potential role of sPLA2 in endothelial cell (EC) migration. Bovine aortic endothelial cells (BAECs) exposed to sPLA2 placed in the lower compartment of a modified Boyden chamber displayed increased migration compared to cells exposed to vehicle. The effect of sP...
متن کاملSurgical Hemostasis
Maintaining appropriate surgical hemostasis is an important component of sound surgical technique and reduces postoperative morbidity and mortality. Intraoperative hemostasis can be achieved by using multiple techniques and hemostatic agents. Factors that must be considered when deciding on an appropriate hemostatic agent include tissue type, characterization of hemorrhage, vessel diameter, and...
متن کاملSoybean Oil Degumming by Immobilized Phospholipase A1
In the present study, we investigated the ability of an immobilized phospholipase A1 (PLA1) in degumming of soybean oil. The enzyme was immobilized by simple adsorption on bentonite without any further modification. The free and immobilized PLA1 were characterized by Fourier Transform InfraRed (FT-IR) spectroscopy and X-Ray Diffraction (XRD). The immobilizat...
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ژورنال
عنوان ژورنال: Drug Target Insights
سال: 2007
ISSN: 1177-3928,1177-3928
DOI: 10.1177/117739280700200019