Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding
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Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding
Purpose The vertebrate rod photoreceptor undergoes daily growth and shedding to renew the rod outer segment (ROS), a modified cilium that contains the phototransduction machinery. It has been demonstrated that ROS shedding is regulated by the light-dark cycle; however, we do not yet have a satisfactory understanding of the molecular mechanisms that underlie this regulation. Given that phototran...
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Rats entrained to a 7 A.M.:7 P.M. lighting cycle had one eye patched and then were placed in either constant light or in a 2 A.M.:2 P.M. lighting cycle. In both cases, the patched eyes maintained the original pattern of rod outer segment (ROS) disc shedding, whereas the open eyes responded to the ambient lighting conditions. When the optic nerves were severed at the optic chiasm, the shedding r...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2017
ISSN: 1552-5783
DOI: 10.1167/iovs.17-21958