Phosphinic acid-based inhibitors of tubulin polyglutamylases
نویسندگان
چکیده
منابع مشابه
Methyl(phenyl)phosphinic acid
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The title compound, C(8)H(11)O(2)P, is a phosphinic compound with a tetra-coordinate penta-valent P atom. The phosphinic function plays a predominant role in the cohesion of the crystal structure, both by forming chains along the b axis via strong inter-molecular O-H⋯O hydrogen bonds and by cross-linking these chains perpendicularly via weak inter-molecular C-H⋯O hydrogen bonds, generating a tw...
متن کاملBenzyl(phenyl)phosphinic acid
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متن کاملBis(3,5-dimethoxyphenyl)phosphinic acid
In the crystal structure of the title compound, C(16)H(19)O(6)P, inter-molecular O-H⋯O inter-actions link the mol-ecules into chains parallel to the b axis. These chains are linked by C-H⋯π and π-π inter-actions [centroid-centroid distance = 3.7307 (29) Å] into a three-dimensional network. The dihedral angle between the benzene rings is 73.5 (1)°. The C and O atoms of all four methoxy groups li...
متن کاملrac-Ethyl(phenyl)phosphinic acid
The crystal structure of the title compound, C8H11O2P, features O-H⋯O hydrogen bonds, which link mol-ecules related by the b-glide plane into chains along [010].
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2013
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.05.069