Phosphatidylinositol 3-kinase and trypsin activation in pancreatitis

Phosphatidylinositol 3-kinase and trypsin activation in pancreatitis.

Acute pancreatitis is a complex inflammatory disease that begins with pancreatic injury and expands to involve multiple organs. Ultimately, the systemic rather than the local effects lead to the morbidity and mortality associated with the disease. However, in terms of prevention it is important to understand the initiation of the disease, which likely occurs within pancreatic acinar cells. The ...

Phosphatidylinositol 3-Kinase Activation Syk Associates with Clathrin and Mediates

Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase

The steroid hormone 1 ,25-dihydroxyvitamin D3 [1 ,25-(OH)2D3] promotes vascular smooth muscle cell (VSMC) growth and calcification, but the precise mechanism by which 1 ,25-(OH)2D3 regulates VSMC migration is unknown. In rat aortic SMCs, we found that 1 ,25-(OH)2D3 (0.1 to 100 nmol/L) induced a dose-dependent increase in VSMC migration. This response required the activation of phosphatidylinosi...

Involvement of Phosphatidylinositol 3-Kinase

Calmodulin activates phosphatidylinositol 3-kinase.

Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector protein, regulates multiple processes in eukaryotic cells, including cytoskeletal organization, vesicular trafficking, and mitogenesis. Phosphatidylinositol 3-kinase participates in events downstream of the receptors for insulin and other...