Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells
نویسندگان
چکیده
منابع مشابه
Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells.
To exploit a novel strategy to regulate T cell-mediated immunity, we established human and murine modified dendritic cells (DCs) with potent immunoregulatory properties (designed as regulatory DCs), which displayed moderately high expression levels of major histocompatibility complex (MHC) molecules and extremely low levels of costimulatory molecules compared with their normal counterparts. Unl...
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Dermal fibroblasts induce maturation of dendritic cells.
To trigger an effective T cell-mediated immune response in the skin, cutaneous dendritic cells (DC) migrate into locally draining lymph nodes, where they present Ag to naive T cells. Little is known about the interaction of DC with the various cellular microenvironments they encounter during their migration from the skin to lymphoid tissues. In this study, we show that human DC generated from p...
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ژورنال
عنوان ژورنال: Vavilov Journal of Genetics and Breeding
سال: 2020
ISSN: 2500-3259,2500-0462
DOI: 10.18699/vj20.659