Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones

Predicting Offspring Performance in Hop (Humulus lupulus L

J. Am. Soc. Brew. Chem. 68(3):125-131, 2010 Genetic information for male and female hop accessions is limited, hampering parental selection to maximize offspring productivity. Our objective was to determine whether amplified fragment length polymorphism (AFLP)derived genetic distance (GDmm) estimates and coancestry estimates from pedigrees (GSped) between parental pairs could be used to predict...

Novel polyketide synthase from Nectria haematococca.

We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria haematococca by complementing a mutant unable to synthesize a red perithecial pigment. pksN encodes a 2,106-amino-acid polypeptide with conserved motifs characteristic of type I PKS enzymatic domains: beta-ketoacyl synthase, acyltransferase, duplicated acyl carrier proteins, and thioesterase. The pksN product groups ...

Assessment report on Humulus lupulus L., flos

DNA sequence and expression variation of hop (Humulus lupulus) valerophenone synthase (VPS), a key gene in bitter acid biosynthesis.

BACKGROUND The hop plant (Humulus lupulus) is a source of many secondary metabolites, with bitter acids essential in the beer brewing industry and others having potential applications for human health. This study investigated variation in DNA sequence and gene expression of valerophenone synthase (VPS), a key gene in the bitter acid biosynthesis pathway of hop. METHODS Sequence variation was ...

Inhibitors of nitric oxide production from hops (Humulus lupulus L.).

Nitric oxide (NO) plays an important role in many inflammatory responses and is also involved in carcinogenesis. In the present study, we investigated the inhibitory effect of extracts from Humulus lupulus L. on both the production of NO and the expression of inducible NO synthase (iNOS) in mouse macrophage RAW 264.7 cells. The production of NO was induced by a combination of lipopolysaccharide...