PhiXing-it, displaying foreign peptides on bacteriophage ΦX174
نویسندگان
چکیده
منابع مشابه
Thermal Stability of RNA Phage Virus-Like Particles Displaying Foreign Peptides
BACKGROUND To be useful for genetic display of foreign peptides a viral coat protein must tolerate peptide insertions without major disruption of subunit folding and capsid assembly. The folding of the coat protein of RNA phage MS2 does not normally tolerate insertions in its AB-loop, but an engineered single-chain dimer readily accepts them as long as they are restricted to one of its two halv...
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Researchers in evolutionary genetics recently have recognized an exciting opportunity in decomposing beneficial mutations into their proximal, mechanistic determinants. The application of methods and concepts from molecular biology and life history theory to studies of lytic bacteriophages (phages) has allowed them to understand how natural selection sees mutations influencing life history. Thi...
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ژورنال
عنوان ژورنال: Virology
سال: 2016
ISSN: 0042-6822
DOI: 10.1016/j.virol.2015.11.021