Philadelphia Chromosome-negative, bcr/abl-positive Chronic Myelogenous Leukemia.

Philadelphia chromosome-negative, bcr/abl-positive chronic myelogenous leukemia.

Chronic myelogenous leukemia(CML)is characterized by the presence of the abnormal chromosome 22, which is termed the Philadelphia chromosome(Ph). The Ph is derived from a translocation between chromosomes 9 and 22, t (9; 22)(q 34; q 11). The c-abl oncogene on the long arm of chromosome 9 fused to the bcr gene on the long arm of chromosome 22 and leads to the formation of a chimeric bcr abl gene...

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.

A cell-line derived from a patient with chronic myelogenous leukemia (CML) is described. The new cell-line, which has over 175 serial passanges in a 3 1/2-yr period, has the following characteristics: (1) CML cells started to proliferate actively since they were first incubated in culture media. A threefold increase in the total number of cells was observed during the first seven passages; the ...

Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia.

Cytogenetic studies of chronic myelogenous leukemia (CML) have shown that the majority of hemopoietic cells originate from pluripotential stem cells affected in this disease. Evidence that lymphocytes are also progeny of these stem cells, however, has been indirect. Philadelphia-chromosome-positive leukemic blasts from a 4 10/12-yr-old boy with CML in blast crisis had features characteristic of...

Philadelphia chromosome positive leukemia.

Variable breakpoints on the Philadelphia chromosome in chronic myelogenous leukemia.

The abl oncogene is translocated from chromosome 9 to 22 in the creation of the Philadelphia (Ph1) chromosome. This article describes new translocation breakpoints identified in two patients with chronic myelogenous leukemia using Southern blotting and cloned human DNA probes from chromosome 9. The translocation breakpoints on chromosome 9 in both of these patients lie closer to the human cellu...