Phenotyping the Clotting System

Phenotyping the clotting system.

The combined research efforts in our field over the last hundred years made that we now recognise dozens of plasma proteins with a function in the clotting system and a set of platelet components that is of the same order. Progress in molecular biology is such as to have identified some one hundred genes that may influence haemostasis and thrombosis and a new one comes about every month. Nevert...

Hybrid-System Modeling of Human Blood Clotting

The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations (which can be written as differential equations) and the latter comprise both threshold-limited behaviors and qualitative facets of the coagulation cascade. We model this proces...

The limits of simulation of the clotting system.

OBJECTIVE To investigate in how far successful simulation of a thrombin generation (TG) curve gives information about the underlying biochemical reaction mechanism. RESULTS The large majority of TG curves do not contain more information than can be expressed by four parameters. A limited kinetic mechanism of six reactions, comprising proteolytic activation of factor (F) X and FII, feedback ac...

Contact activation in the extrinsic blood clotting system.

Understanding and treating disorders of the clotting system.

DECEMBER 2007 • 20(12) • JAAPA 21 EARN CATEGORY I CME CREDIT by reading this article and the article beginning on page 42 and successfully completing the posttest on page 47. Successful completion is defined as a cumulative score of at least 70% correct. This material has been reviewed and is approved for 1 hour of clinical Category I (Preapproved) CME credit by the AAPA. The term of approval i...