Phenotyping for CYP2C19 deficiency by omeprazole as a probe drug in Japanese
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چکیده
منابع مشابه
Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.
The aim of this study was to evaluate the contribution of metabolites to drug-drug interactions (DDI) using the inhibition of CYP2C19 and CYP3A4 by omeprazole and its metabolites as a model. Of the metabolites identified in vivo, 5-hydroxyomeprazole, 5'-O-desmethylomeprazole, omeprazole sulfone, and carboxyomeprazole had a metabolite to parent area under the plasma concentration-time curve (AUC...
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Background and purpose: This study aimed at investigating the effects of 3,4-Methylenedioxymethamphetamine (MDMA) on liver cytochrome 2C19 enzyme activity, which is a major liver enzyme in the metabolism of a wide range of drugs, using omeprazole as a probe of the CYP2C19 activity in isolated perfused rat liver. Materials and methods: This experimental study was done in 20 male Sprague–Da...
متن کاملDrug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer
PURPOSE A microdose drug-drug interaction (DDI) study may be a valuable tool for anticipating drug interaction at therapeutic doses. This study aimed to compare the magnitude of DDIs at microdoses and regular doses to explore the applicability of a microdose DDI study. PATIENTS AND METHODS Six healthy male volunteer subjects were enrolled into each DDI study of omeprazole (victim) and known p...
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This article investigates into the feasibility of using gamma radiation Compton backscatter spectra as a means of material characterization, with the view to developing a portable, hand held probe for investigative purposes such as searching for illicit substances hidden in wall or car door cavities.
متن کاملCYP2C19 Phenoconversion by Routinely Prescribed Proton Pump Inhibitors Omeprazole and Esomeprazole: Clinical Implications for Personalized Medicine.
The phenotype pantoprazole-(13)C breath test (Ptz-BT) was used to evaluate the extent of phenoconversion of CYP2C19 enzyme activity caused by commonly prescribed proton pump inhibitors (PPI) omeprazole and esomprazole. The Ptz-BT was administered to 26 healthy volunteers and 8 stable cardiovascular patients twice at baseline and after 28 days of PPI therapy to evaluate reproducibility of the Pt...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)46618-3