Phenotyping Chronic Lung Allograft Dysfunction Using Body Plethysmography and Computed Tomography

Chronic lung allograft dysfunction: evolving practice.

PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...

Chronic lung allograft dysfunction following lung transplantation: challenges and solutions

Total lung capacity by plethysmography and high-resolution computed tomography in COPD

AIM To characterize and compare total lung capacity (TLC) measured by plethysmography with high-resolution computed tomography (HRCT), and to identify variables that predict the difference between the two modalities. METHODS Fifty-nine consecutive patients referred for the evaluation of COPD were retrospectively reviewed. Patients underwent full pulmonary function testing and HRCT within 3 mo...

Chronic renal allograft dysfunction.

The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...

Diastolic dysfunction and computed tomography.

c s w d Left ventricular (LV) diastolic dysfunction is being increasingly recognized as a marker of risk both in ischemic and nonischemic cardiomyopathies. In fact, the syndrome of congestive heart failure, classically considered a hallmark of systolic dysfunction, can be completely dependent on diastolic dysfunction of the LV (1), and its long-term prognosis is similarly poor. In the natural h...