Phenotypic variability and genetic susceptibility to genomic disorders
نویسندگان
چکیده
منابع مشابه
Phenotypic variability and genetic susceptibility to genomic disorders.
The duplication architecture of the human genome predisposes our species to recurrent copy number variation and disease. Emerging data suggest that this mechanism of mutation contributes to both common and rare diseases. Two features regarding this form of mutation have emerged. First, common structural polymorphisms create susceptible and protective chromosomal architectures. These structural ...
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Recent technological advances in genetic manipulations and DNA microarrays are profoundly altering the landscape of biological research, offering opportunities to investigate biological questions that were only dreamed of a few years ago. With this revolution comes the hope of being able to tackle some of the more arduous challenges that the central nervous system has presented to the research ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2010
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddq366