منابع مشابه
Epigenetic control of phenotypic plasticity in a filamentous fungus Neurospora crassa
Phenotypic plasticity is the ability of a genotype to produce different phenotypes under different envi2 ronmental or developmental conditions. Phenotypic plasticity is an ubiquitous feature of living organisms, and is typically based on variable patterns of gene expression. However, the mechanisms by which gene 4 expression is influenced and regulated during plastic responses are poorly unders...
متن کاملSpontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag.
We calculated a spontaneous rate of 26-37 x 10(-6) mutations per cell division for L5178Y MOLY (mouse lymphoma) cells at the thymidine kinase locus (tk+/(-)----tk-/-) using a procedure that isolated and segregated cells during expression. This rate was 50 times higher than when cells expressed the mutant phenotype in suspension. The higher mutation rates obtained with the in situ procedure sugg...
متن کاملEpigenetic Control of Phenotypic Plasticity in the Filamentous Fungus Neurospora crassa
Phenotypic plasticity is the ability of a genotype to produce different phenotypes under different environmental or developmental conditions. Phenotypic plasticity is a ubiquitous feature of living organisms, and is typically based on variable patterns of gene expression. However, the mechanisms by which gene expression is influenced and regulated during plastic responses are poorly understood ...
متن کاملSimple Sequence Repeats Provide a Substrate for Phenotypic Variation in the Neurospora crassa Circadian Clock
BACKGROUND WHITE COLLAR-1 (WC-1) mediates interactions between the circadian clock and the environment by acting as both a core clock component and as a blue light photoreceptor in Neurospora crassa. Loss of the amino-terminal polyglutamine (NpolyQ) domain in WC-1 results in an arrhythmic circadian clock; this data is consistent with this simple sequence repeat (SSR) being essential for clock f...
متن کاملlac‐1 and lag‐1 with ras‐1 affect aging and the biological clock in Neurospora crassa
Using an automated cell counting technique developed previously (Case et al., Ecology and Evolution 2014; 4: 3494), we explore the lifespan effects of lac-1, a ceramide synthase gene paralogous to lag-1 in Neurospora crassa in conjunction with the band bd (ras-1) gene. We find that the replicative lifespan of a lac-1KObd double mutants is short, about one race tube cycle, and this double mutant...
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ژورنال
عنوان ژورنال: Heredity
سال: 1960
ISSN: 0018-067X,1365-2540
DOI: 10.1038/hdy.1960.18