Phenotypic characterization of R-factor tetracycline resistance determinants
نویسندگان
چکیده
منابع مشابه
R-factor-mediated resistance to tetracycline in Proteus mirabilis.
The expression of R-factor-mediated resistance to tetracycline has been compared in Proteus mirabilis and Escherichia coli. Resistance to a range of concentrations of tetracycline was significantly lower in P. mirabilis than in E. coli in both induced and repressed states. Indirect evidence showed that conditions which result in a marked increase in the level of resistance of P. mirabilis harbo...
متن کاملHeterogeneity of tetracycline resistance determinants in Streptococcus.
We found that naturally occurring tetracycline resistance in streptococci is encoded by more than one genetic determinant. Two of these distinct determinants were cloned, and the regions that are necessary and sufficient for expression of tetracycline resistance were defined by deletion analysis. These cloned determinants were further characterized by DNA-DNA hybridization experiments which als...
متن کاملNomenclature for new tetracycline resistance determinants.
Letters of the English alphabet have heretofore been used to name tetracycline resistance determinants. Since all 26 letters have now been used, a nomenclature employing numerals is recommended for future determinants, and one laboratory has offered to coordinate the assignment of numerals.
متن کاملCharacteristics and expression of tetracycline resistance in gram-negative bacteria carrying the Pseudomonas R factor RP1.
The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycline accumulation by RP1-containing organisms. The tetracycline resistance mecha...
متن کاملActive efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
Tetracycline resistance encoded by four genetically different determinants residing on plasmids in Escherichia coli was shown to be associated in each case with an energy-dependent decrease in accumulation of the antibiotic in whole cells in which resistance had been induced. The different class determinants examined were those on plasmids RP1 (class A), R222 (class B), R144 (class C), and RA1 ...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1974
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300015330