Phenotypic and molecular biological analysis of human butyrylcholinesterase variants
نویسندگان
چکیده
منابع مشابه
Novel Human Butyrylcholinesterase Variants: Toward Organophosphonate Detoxication
Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates. Herein, we describe the use of a molecular evolution method to develop novel hBChE variants with increased resistance to stereochemically defined nerve agent model compounds of soman, sarin, and cyclosarin. Novel hBChE variants (Y3...
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BACKGROUND Prolonged apnoea following injection of ester-containing myoralaxants was first described in 1953. Because a large part of administered succinylcholine is shortly hydrolyzed by plasma butyrylcholinesterase (BChE) under normal conditions, prolonged apnoea was attributed to deficiency in BChE. It was found that BChE deficiency was due to genetic variations. Human BChE gene shows a larg...
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ژورنال
عنوان ژورنال: Clinical Biochemistry
سال: 1990
ISSN: 0009-9120
DOI: 10.1016/0009-9120(90)90187-y