Phemphigus vulgaris an autoimmune acantholysis: a case report
نویسندگان
چکیده
منابع مشابه
Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists.
BACKGROUND Pemphigus vulgaris (PV) is an autoimmune, IgG autoantibody-mediated disease of skin and mucosa leading to progressive blistering and nonhealing erosions. Patients develop autoantibodies to adhesion molecules mediating intercellular adhesion and to keratinocyte cholinergic receptors regulating cell adhesion. OBSERVATIONS To determine whether a cholinergic agonist can abolish PV IgG-...
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Pemphigus vulgaris (PV) is a potentially fatal autoimmune mucocutaneous blistering disease. Although PV occurs predominantly in adulthood, in the 3rd to 5th decades of life, there have rarely been reports of childhood cases which are often misdiagnosed. It presents as oral blisters that rupture rapidly and progress to painful erosions. Most patients develop cutaneous flaccid blisters that ruptu...
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Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous diseases characterized by flaccid blisters and/or pustules, with secondary erosions of the mucous membranes / skin. Pemphigus vulgaris is threatening patient life by the formation of splits within the epidermis, accompanied by acantholysis (separation of keratinocytes from each other). In this article, a term female neo...
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متن کاملApoptosis is not required for acantholysis in pemphigus vulgaris.
The autoimmune blistering skin disease pemphigus vulgaris (PV) is caused primarily by autoantibodies against desmosomal cadherins. It was reported that apoptosis can be detected in pemphigus skin lesions and that apoptosis can be induced by PV-IgG in cultured keratinocytes. However, the role of apoptosis in PV pathogenesis is unclear at present. In this study, we provide evidence that apoptosis...
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ژورنال
عنوان ژورنال: International Journal of Research in Dermatology
سال: 2020
ISSN: 2455-4529
DOI: 10.18203/issn.2455-4529.intjresdermatol20204572