Phase uncertainty in case-control association studies
نویسندگان
چکیده
منابع مشابه
Genetic case-control association studies in neuropsychiatry.
Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care...
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The Cochran-Armitage trend test (CATT) is well suited for testing association between a marker and a disease in case-control studies. When the underlying genetic model for the disease is known, the CATT optimal for the genetic model is used. For complex diseases, however, the genetic models of the true disease loci are unknown. In this situation, robust tests are preferable. We propose a two-ph...
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To test for genetic association between a marker and a complex disease using a case-control design, Cochran-Armitage trend tests (CATTs) and Pearson's chi-square test are often employed. Both tests are genotype-based. Song and Elston (Statist. Med. 2006; 25:105-126) introduced the Hardy-Weinberg disequilibrium trend test and combined it with CATT to test for association. Compared to using a sin...
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Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical model for testing haplotype-haplotype interactions for human diseases with a case-control genetic ass...
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Case-control association studies are widely used in the search for genetic variants that contribute to human diseases. It has long been known that such studies may suffer from high rates of false positives if there is unrecognized population structure. It is perhaps less widely appreciated that so-called "cryptic relatedness" (i.e., kinship among the cases or controls that is not known to the i...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2009
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.20399