منابع مشابه
Phase separation in lipid membranes.
Cell membranes show complex behavior, in part because of the large number of different components that interact with each other in different ways. One aspect of this complex behavior is lateral organization of components on a range of spatial scales. We found that lipid-only mixtures can model the range of size scales, from approximately 2 nm up to microns. Furthermore, the size of compositiona...
متن کاملCharge-induced phase separation in lipid membranes.
Phase separation in lipid bilayers that include negatively charged lipids is examined experimentally. We observed phase-separated structures and determined the membrane miscibility temperatures in several binary and ternary lipid mixtures of unsaturated neutral lipid, dioleoylphosphatidylcholine (DOPC), saturated neutral lipid, dipalmitoylphosphatidylcholine (DPPC), unsaturated charged lipid, d...
متن کاملDigital holographic microscopy of phase separation in multicomponent lipid membranes.
Lateral in-homogeneities in lipid compositions cause microdomains formation and change in the physical properties of biological membranes. With the presence of cholesterol and mixed species of lipids, phospholipid membranes segregate into lateral domains of liquid-ordered and liquid-disordered phases. Coupling of two-dimensional intralayer phase separations and interlayer liquid-crystalline ord...
متن کاملPhase Transitions in Lipid Membranes
The seminar treats phase transitions in lipid membranes, with the focus on the main lipid bilayer phase transition. It reveals the microscopic picture and reviews the key factors leading to the presented phenomena. A general discussion on models is made and some concrete examples are presented in more detail. Finally, experimental approaches to study the phase behavior of lipid membranes are di...
متن کاملThree-Phase Coexistence in Lipid Membranes.
Phospholipid ternary systems are useful model systems for understanding lipid-lipid interactions and their influence on biological properties such as cell signaling and protein translocation. Despite extensive studies, there are still open questions relating to membrane phase behavior, particularly relating to a proposed state of three-phase coexistence, due to the difficulty in clearly disting...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2011
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a004630