Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients
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چکیده
منابع مشابه
Immunological monitoring of metastatic colorectal cancer patients undergoing active specific immunotherapy with a poly-epitope peptide vaccine (TSPP) to thymidylate synthase in combination with GOLFIG chemoimmunotherapy regimen
Background: TSPP is a 27 poly-epitope peptide anti-cancer vaccine which includes the amino acidic sequences of 3 known CTL-epitopes with HLA-A(*)02.01 binding motifs, contained in the thymidylate synthase (TS), a tumourassociated enzyme antigen critical for DNA synthesis and repair. The immunological and antitumor activity of TSPP has already been tested in preclinical studies, whose results of...
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ژورنال
عنوان ژورنال: Cancer Immunology, Immunotherapy
سال: 2015
ISSN: 0340-7004,1432-0851
DOI: 10.1007/s00262-015-1711-7