Pharmacology of natural radioprotectors

22 DNA - Binding Radioprotectors

Application of Radioprotectors in Radiation Protection

Possibility of protection from ionizing radiation when an organism, as a unit, absorbs radiated energy practically does not exist. In the previous investigations no medicine has been invented that could successfully be applied in therapy of radiation diseases. Today, in the cases of accidental irradiation with high doses of ion radiation and developing of radiation syndrome, today it is possibl...

Natural Alkamides: Pharmacology, Chemistry and Distribution

Alkamides are a broad and expanding group of bioactive natural compounds found in at least 33 plant families. Despite the relatively simple molecular architecture of alkamides (fig. 1), these natural products show broad structural variability and an important range of biological activities, such as immunomodulatory, antimicrobial, antiviral, larvicidal, insecticidal, diuretic, pungent, analgesi...

Organoselenium Compounds: A New Generation of Radioprotectors

Exposure of living organisms to ionizing radiation can cause health hazards and radioprotectors are employed to minimize such unwanted effects. Over the years a number of sulfhydryl compounds have been examined for radioprotection and only one agent, amifostine, is approved in the clinic. Selenium, a higher analogue of sulfur, is a micronutrient and a constituent of redox enzymes like glutathio...

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compou...