منابع مشابه
Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities.
It is now well established that any given ligand for a G-protein-couple receptor (GPCR) does not simply possess a single defined efficacy. Rather, a ligand possesses multiple efficacies, depending on the specific down-stream signal transduction pathway analyzed. This diversity may be based on ligand-specific GPCR conformations and is often referred to as "functional selectivity." It has been kn...
متن کاملStereoisomers of hydroxyproline.
Hydroxy-L-proline was first isolated by Fischer in 1902 from a hydrolysate of gelatin (l).l The synthesis and determination of the structure were reported by Leuchs and coworkers (5--g), and, in 1919, the separation of the two racemic stereoisomers and the resolution of each racemate through mixtures of quinine with the corresponding N-phenylisocyanate derivatives were accomplished (5). In the ...
متن کاملType-Itemized Enumeration of RS-Stereoisomers of Octahedral Complexes
Stereoisograms of octahedral complexes are classified into five types (type I--typeV) under the action of the corresponding RS-stereoisomeric group. Their enumeration is accomplished in a type-itemized fashion, where Fujita's proligand method developed originally for combinatorial enumeration under point groups (S. Fujita, Theor. Chem. Acc., 113, 73--79 (2005)) is extended to meet the requireme...
متن کاملGas-chromatographic separation of stereoisomers of dipeptides.
Synthetic dipeptides comprising mixtures of enantiomers, diastereomers, or sequential isomers were converted into their N-perfluoroacetyl dipeptide esters (perfluoroacetyl: trifluoroacetyl, pentafluoroacetyl, heptafluorobutyryl; ester: methyl, 1-propyl, 2-propyl, 2,2,2-trifluoroethyl) and analyzed by GC-MS on the chiral stationary phases Chirasil-L-Val and Lipodex-E using helium as carrier gas....
متن کاملComparative Anticonvulsant Study of Epoxycarvone Stereoisomers.
Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (-)-cis-EC, (+)-trans-EC, and (-)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the ani...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1929
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.15.1.63