Pharmacological superiority of nobiletin-rich <i>Citrus reticulata</i> peel, a multicomponent drug, over nobiletin alone regarding anti-dementia action
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منابع مشابه
Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
Alzheimer's disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the last three decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, success...
متن کاملAnti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin.
We investigated the effects of water and ethyl acetate extracts of Citrus unshiu peel (Aurantii Nobilis pericarpium) on hepatitis C virus (HCV) absorption in MOLT-4 cells (a human lymphoblastoid leukemia cell line). By reverse transcription polymerase chain reaction (RT-PCR), we showed that both the ethyl acetate layer of Citrus unshiu peel extract and fraction 7 decreased HCV absorption in MOL...
متن کاملPharmacological actions of nobiletin in the modulation of platelet function
BACKGROUND AND PURPOSE The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the antiplatelet properties of flavonoids, little is known about the mechanisms by which flavonoids inhibit platelet function. In this study, we aimed to explore the pharmacological effects of...
متن کاملUpregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP
Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP Junko Kimura1, Kosuke Shimizu1, Jiro Takito2, Kiyomitsu Nemoto3, Masakuni Degawa3, Akihito Yokosuka4, Yoshihiro Mimaki4, Naoto Oku1, Yasushi Ohizumi1,5 1 Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan 2 ...
متن کامل[A new strategy for preventive and functional therapeutic methods for dementia--approach using natural products].
Alzheimer's disease (AD) has become a serious social problem in Japan. However, effective preventive and fundamental therapeutic methods for AD have not yet been developed. Using a new strategy in the course of our survey of numerous natural resouces having neurotrophic activity, we isolated a variety of active constituents and proved their pharmacological properties. As a result, we successful...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2015
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.145.229