Pharmacological regulation of neutrophil activity and apoptosis
نویسندگان
چکیده
منابع مشابه
Pharmacological regulation of neutrophil activity and apoptosis
Novel strategies of antiinflammatory therapy are based upon pharmacological agents capable to enhance the resolution - i.e. the termination of the beneficial inflammation before it may turn into an adverse chronic stage. In contrast to the current therapy, which antagonises the formation of proinflammatory mediators, the "proresolving" therapy promotes natural antiinflammatory processes. It is ...
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Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role in the regulation of neutrophil apoptosis. The protein has some unusual properties compared with other family members, including an extremely high turnover ra...
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Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors.
As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a num...
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The serine/threonine kinase, Akt, also known as PKB (Protein Kinase B) is one important signal transduction pathway that mediates the delay of neutrophil apoptosis caused by inflammatory mediators. Proteins controlled by the PKB/Akt pathway have been reported to prevent or reverse apoptotic-signaling pathways and regulate cell survival. In this review we discuss the role of PKB/Akt activation i...
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ژورنال
عنوان ژورنال: Interdisciplinary Toxicology
سال: 2011
ISSN: 1337-9569,1337-6853
DOI: 10.2478/v10102-011-0003-0